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Friday, 24 August 2012 17:10

Recurrent miscarriage 'caused by super-fertility'

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Women who suffer recurrent miscarriages could actually be “super-fertile”, say specialists.

They have found some women who repeatedly lose their babies early in pregnancy, do so because they are too good at letting imperfect embryos implant in the uterus.

Professor Nick Macklon, a consultant in obstetrics and gynaecology at the Princess Anne Hospital in Southampton, said many women who suffered repeated miscarriage “feel guilty that they are simply rejecting their pregnancy”.

He continued: “But we have discovered it may not be because they cannot carry; it is because they may simply be super-fertile, as they allow embryos which would normally not survive to implant."

Prof Macklon, working with colleagues at University Medical Center Utrecht in the Netherlands, compared cells from the lining of the wombs of women who have suffered recurrent miscarriage and those with normal fertility cycles.

They found cells from those with recurrent miscarriage move towards embryos, encouraging implantation regardless of quality, but those from normally fertile women were selective.

He explained: "Only around 30 per cent of natural conceptions makes it to a baby and the rest are lost early in pregnancy. Mercifully, most women remain unaware of these losses because they happen before they miss their period.

"When poorer embryos are allowed to implant, they may last long enough in cases of recurrent miscarriage to give a positive pregnancy test."

Prof Macklon, who is chair of obstetrics and gynaecology at the University of Southampton, said the research, published in journal PLoS ONE, was a significant moment for sufferers.

He said: "For the first time, women who have suffered with this extremely difficult problem can take some comfort by having a clearer understanding of the causes and realising they are not bad at carrying but perhaps too good.

"With much better understanding of how the female body selects - or doesn't select - embryos, we hope to now explore ways we can fix this."

 news sorce: The telegraph

Read 2320 times Last modified on Friday, 24 August 2012 18:04

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