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Friday, 23 March 2012 07:25

Can music prevent Heart Transplant Rejection in Human also?

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New research published in BioMed Central's open access journalJournal of Cardiothoracic Surgery demonstrates that music can reduce rejection of heart transplants in mice by influencing the immune system-Medical Express

Each of us may have experience the influence of music on our mind, music had fundamental affect on humans. Many mythological stories reveal the powerful effect of music on ourselves and atmosphere. Currrently the scientific version that is Music therapy had help many to get rid of various health problems.
Music can reduce stress, enhance relaxation and also distract you from pain.

Although, the link between the immune system and brain function is not clearly understood, clinically music had been found effective in reducing anxiety post heart attack, to reduce pain and nausea during bone marrow transplantation. These suggest that music may act via parasympathetic nervous system that regulates the bodily functions which are not consciously under our control.

Researchers from Japan investigated if music could influence the survival of heart transplant in mice. They found that opera and classical music both increased the time before the transplanted organs failed, but single frequency monotones and new age music did not.

The team led by Dr Masanori Niimi pinpointed the source of this protection to the spleen. Dr Uchiyama and Jin revealed, "Opera exposed mice had lower levels of interleukin-2 (IL-2) and interferon gamma (IFN-γ). They also had increased levels of anti-inflammatory IL-4 and IL-10. Significantly these mice had increased numbers of CD4+CD25+ cells, which regulate the peripheral immune response."

It seems that music really does influence the immune system – although the mechanism behind this still is not clear. Additionally, this study only looked at a limited selection of composers, so the effect of music on reducing organ rejection may not be limited to opera.- Medical express.

More information: Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained generation of regulatory CD4+CD25+ cells, Masateru Uchiyama, Xiangyuan Jin, Qi Zhang, Toshihito Hirai, Atsushi Amano, Hisashi Bashuda and Masanori Niimi, Journal of Cardiothoracic Surgery (in press)

Provided by BioMed Central


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Read 4238 times Last modified on Friday, 23 March 2012 07:39

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